129S.129P2-Cited2tm1Bha/H

Status: Available to order

EMMA ID: EM:02570

International strain name: 129S.129P2-Cited2tm1Bha/H

Alternative name: Cited2-tm1Bha -129

Strain type: Targeted Mutant Strains : Knock-out

Allele symbol: Cited2tm1Bha

Allele name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; targeted mutation 1, Shoumo Bhattacharya

Gene symbol: Cited2

Gene name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

Information from provider

Provider: Shoumo Bhattacharya

Provider affiliation: University of Oxford

Genetic information: Targeting construct is derived from 129 DNA. A neomycin-resistance gene cassette replaces all Cited2 exons.

Phenotypic information: Cardiac malformations, adrenal agenesis, fusion of cranial ganglia, abnormal cardiac neural crest migration, exencephaly and left-right patterning defects.

Breeding history: The line is maintained by backcrossing to 129S6/SvEv. It has been backcrossed 10+ generations.

Homozygous viable?: No

Homozygous fertile?: No

Homozygous matings required?: No

Immunocompromised?: No

References:

  • Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.; Bamforth S D, Bragança J, Eloranta J J, Murdoch J N, Marques F I, Kranc K R, Farza H, Henderson D J, Hurst H C, Bhattacharya S; 2001; Nature genetics; 29; 469-74; 11694877

Information from EMMA

Archiving centre: MRC, Medical Research Council, Harwell, United Kingdom

Animals used for archiving: Males were heterozygous (129S9/SvEvH)

Material in repository: Sperm from heterozygous males / rederivation will yield heterozygous or wild-type mice

Breeding at archiving centre: Imported males were backcrossed to 129S9/SvEvH before heterozygous sperm was archived

Disease information

Orphanet associated rare diseases, based on orthologous gene matching

  • Atrial septal defect, ostium secundum type / ORPHA:99103
  • Atrial septal defect, sinus venosus type / ORPHA:99105

Phenotype information

MGI associated phenotypes (allele matching)

abnormal interventricular septum morphology

double outlet right ventricle

abnormal pulmonary trunk morphology

edema

postnatal lethality

right pulmonary isomerism

dextrocardia

mesocardia

small spleen

abnormal embryo turning

persistent truncus arteriosis

situs inversus

abnormal aortic arch morphology

interrupted aortic arch

right aortic arch

abnormal direction of heart looping

right atrial isomerism

abnormal inferior vena cava morphology

ventricular septal defect

common atrioventricular valve

abnormal tail position or orientation

abnormal heart ventricle morphology

absent adrenal gland

abnormal cardiac outflow tract development

ostium primum atrial septal defect

common atrium

vascular ring

abnormal heart development

overriding aortic valve

abnormal kidney development

exencephaly

fused dorsal root ganglion

small dorsal root ganglion

abnormal cranial ganglia morphology

abnormal heart atrium morphology

abnormal heart position or orientation

atrial septal defect

aberrant origin of the right subclavian artery

perinatal lethality, complete penetrance

embryonic lethality during organogenesis, incomplete penetrance

abnormal cardiac neural crest cell morphology

decreased cardiac neural crest cell number

absent cardiac neural crest cells

MGI associated phenotypes (gene matching)

decreased embryo size

ventricular septal defect

edema

abnormal type I pneumocyte morphology

abnormal interventricular septum morphology

atrial septal defect

iris coloboma

fused dorsal root ganglion

abnormal neural tube morphology

right pulmonary isomerism postnatal lethality

absent cardiac neural crest cells

double outlet right ventricle

no abnormal phenotype detected

abnormal stomach position or orientation

abnormal lung development

persistent truncus arteriosis

perinatal lethality, complete penetrance

absent adrenal gland

abnormal cardiac neural crest cell morphology

abnormal heart position or orientation

homeostasis/metabolism phenotype

ostium primum atrial septal defect

abnormal neural fold formation

hydrops fetalis

abnormal aortic arch morphology

dextrocardia

overriding aortic valve

impaired lung alveolus development

abnormal cranial ganglia morphology

abnormal heart ventricle morphology

right-sided isomerism

situs inversus

absent alveolar lamellar bodies

aberrant origin of the right subclavian artery

increased embryonic neuroepithelium apoptosis

interrupted aortic arch

abnormal heart and great artery attachment

abnormal inferior vena cava morphology

lethality throughout fetal growth and development, complete penetrance

abnormal heart morphology

abnormal spinal cord central canal morphology

abnormal blood flow velocity

exencephaly

abnormal heart development

abnormal direction of heart looping

abnormal pulmonary trunk morphology

abnormal embryo turning

abnormal cardiac outflow tract development

small lung lobe

abnormal tail position or orientation

mesocardia

pulmonary artery stenosis

decreased atrioventricular cushion size

right aortic arch

abnormal left-right axis patterning

abnormal pulmonary alveolus epithelial cell morphology

abnormal surfactant secretion

prenatal lethality, incomplete penetrance

atrioventricular valve regurgitation

embryonic lethality during organogenesis, incomplete penetrance

small dorsal root ganglion

right atrial isomerism

open neural tube

small spleen

decreased cardiac neural crest cell number

abnormal type II pneumocyte morphology

abnormal basicranium morphology

abnormal heart atrium morphology

abnormal truncus arteriosus septation

abnormal pulmonary alveolus morphology

abnormal neurocranium morphology

common atrioventricular valve

abnormal kidney development

common atrium

decreased fetal size

vascular ring

abnormal atrioventricular cushion morphology

Literature references

  • Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.; Bamforth S D, Bragança J, Eloranta J J, Murdoch J N, Marques F I, Kranc K R, Farza H, Henderson D J, Hurst H C, Bhattacharya S; 2001; Nature genetics; 29; 469-74; 11694877

Order

Availabilities

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1600*
  • Rederivation of mice from frozen stock. Ready for delivery 4-6 months after paperwork in place. €3200*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Strain detail sheet

Example health report
(Current health report will be provided later)

MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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